"It took more than four years, a double mastectomy, and multiple other surgeries—as well as radiation treatments and bad reactions to ineffective chemotherapy drugs—before Christine Hanson's breast cancer was brought under control by Dr. Mark Fesen in Hutchinson, Kan. By then, cancer had spread to her lungs, liver, and brain.
Through a port implanted in her chest nearly five years ago to reduce stress on her veins, Hanson, the mother of three children not yet in high school, has been getting weekly infusions of cancer-treatment drugs Avastin and Abraxane, which have put her cancer into remission.
What if doctors had a detailed road map of the kinds of drugs and therapies that Hanson's genetic makeup makes her most receptive to, instead of having to arrive at treatments through the costly—and sometimes painful—method of trial and error?
That's the promise of the nascent field of personalized medicine, where treatment is prescribed based on an understanding
how an individual's body is genetically predisposed to welcome or resist certain compounds. The day when customized treatment is widely available may soon be within reach, thanks to technological advances being made by life science tools companies. They develop and market protein-separation devices and other instruments that will eventually provide researchers with the knowledge needed to precisely target the best treatment for life-threatening illnesses.
After bureaucratic delays this year that frustrated investors, the awarding of $10 billion to the National Institutes of Health under the Obama Administration's stimulus program over the next two years is likely to give a big boost to life science companies' earnings as the money funds a fresh wave of research.
It's been less than seven years since completion of the momentous Human Genome Project, which took 13 years and an estimated $3.8 billion to map humanity's genetic material.
Sequencing an individual's DNA currently costs about $50,000 and there's a road map to get it down to $1,000 within three to five years, say equity analysts who cover the industry.
Drug companies have been reluctant to embrace personalized medicine because
it's easier to sell a less-targeted drug to a broader population than to market more narrowly applied drugs to smaller populations.
Although the future medical research prospects are lucrative by themselves, some analysts see a much bigger opportunity in applications across such other industries as environmental monitoring, water treatment, food safety, and forensics—all driven by stricter global regulation.
"These technologies' ability to differentiate and quantify compounds in a quick, cheap, and efficient manner makes them applicable to lots of other industries," says McCormack. "Early applications were in life sciences where the compounds in question were drugs. As we move forward, the compounds are air, water, and food, and you're trying to find the elements that don't belong or that we need to remove."