Theano 600 B.C. Greek mathematician, married Pythagoras, devised "The Golden Rectangle" (which paved the way for Pascal's triangle and Fibonacci's series)
Trotula of Salerno around 1097; Famous OB/GYN , wrote books that were used for hundreds of years after her death, She studied complications of childbirth and how to avoid them.
Sybilla Masters around 1720 - american inventor, a quaker, most noted for creating a method for curing indian corn for colonists, first american female inventor.
Laura Bassi 1711-1778 , italian scientists, Volta's works were built on her initial research.
Maria Gaetana Agnesi 1718-1799 , Child Prodigy, you can still find her algebraic solution in text books today
Witch of Agnesi
Caroline Herschel 1750-1848 she and her brother discovered Uranus.
Mary Edwards Walker 1832-1919 Physician, awarded the Medal of Honor in 1866 for her work during the civil war, the first and only civilian/woman to receive this medal.
Williamina Paton Stevens Fleming 1851-1911 Scottish immigrant to boston. astronomer , devised a system of classifying stars according to their spectra, which is a distintive pattern produces by each star when its light is passed through a prism. She discovered 59 nebulae, over 300 variable stars, and 10 novae,(Draper Catalogues of Stellar Spectra). 1906 became the first american women elected to the royal astronomical society. published a total of 222 variable stars in 1907.
Evelyn Boyd Granville 1924-present, mathematician , worked with IBM n a team that was responsible for the formulation of orbit computations and computer procedures for NASA
need I say more?